교수
홍승환 Hong, Seung Hwan
연구분야
세포생물학
1. Study for genes regulated by STAT3 transcription factor
● Identification of STAT3-downstream genes in embryonic stem (ES) cells
● Search for the function of STAT3-downstream genes in ES cells
● Self-renewal and differentiation of ES cells
2. cAMP-signaling pathways during growth inhibition and apoptosis in cancer cells
● Anticancer activity of 8-Cl-cAMP
● Cross-talk of cAMP signaling with other pathways : PKC, AMPK, MAPK, Rap1 etc.
● Identification of STAT3-downstream genes in embryonic stem (ES) cells
● Search for the function of STAT3-downstream genes in ES cells
● Self-renewal and differentiation of ES cells
2. cAMP-signaling pathways during growth inhibition and apoptosis in cancer cells
● Anticancer activity of 8-Cl-cAMP
● Cross-talk of cAMP signaling with other pathways : PKC, AMPK, MAPK, Rap1 etc.
학력/경력
학력
- - 1985.2-1987.5 박사 : Albert Einstein College of Med
- - 1982.2-1985.1 석사: Albert Einstein College of Med
- - 1978.3-1981.2 석사: 서울대학교
- - 1974.3-1978.2 학사: 서울대학교
경력
- - 2008 ~ 2008 교무부학장 서울대 자연과학대학
- - 2007 ~ 2008 기획실장 서울대 자연과학대학
- - 2006 ~ 2007 수의예과장 서울대 자연과학대학 수의예과
- - 2006 ~ 2007 의예과장 서울대 자연과학대학 의예과
- - 2003 ~ 2005 기초과학교육연구공동기기원장 서울대 기초과학공동기기원
- - 2001 ~ 2003 분자세포생물학연구소장 서울대 기초과학연구원
주요논문
- Han, JH, Ahn YH, Choi Y, Hong SH (2009) Involvement of AMP-Activated Protein Kinase and p38 Mitogen-Activated Protein Kinase in 8-Cl-cAMP-Induced Growth Inhibition. J Cell Physiol 218: 104-112.
- Ahn YH, Han JH, Hong SH (2006) Rap1 and p38 MAPK Mediate 8-Chloro-cAMP-Induced Growth Inhibition in Mouse Fibroblast DT Cells. J Cell Physiol 209: 1039-1045.
- Ko SY, Kang HY, Lee HS, Han SY, Hong SH (2006) Identification of Jmjd1a as a STAT3 Downstream Gene in mES Cells. Cell Struct Funct 31: 53-62.
- Kim SG, Kim HA, Jong HS, Park JH, Kim NK, Hong SH, Kim TY, Bang YJ (2005) The endogenous ratio of Smad2 and Smad3 influences the cytostatic function of Smad3. Mol Biol Cell 16: 4672-4683.
- Ahn YH, Jung JM, Hong SH (2005) 8-Chloro-cyclic AMP-induced growth inhibition and apoptosis is mediated by p38 mitogen-activated protein kinase activation in HL60 cells. Cancer Res 65: 4896-4901.