[초청강연] Temporally-mediated Strategies for Neuropsychiatric Treatment Development and Optimization.

Neuropsychiatric disorders are being increasingly considered as forms of consolidated,maladaptive synaptic process (“memory”). As such, recent advances in the learning andmemory field have provided new insights into potential mechanisms that may underlie theirlong-term durability (i.e., chronic clinical courses). Furthermore and perhaps more importantly,they have provided new opportunities for rationally-designed treatment strategies, which arebased not only on specific mechanisms but also on the underlying neurobiological processes(i.e., temporally-integrated output of individual mechanisms). Thus, desired neuropsychiatrictreatment outcomes (restoration of “normal” psychic functions) may be best achieved by notmerely targeting individual mechanisms (“what”) but optimizing the treatment regimen (“how”and “when”). In my presentation, I will describe a set of novel combination treatments, whichconsists of specific combinations of clinically-available drugs and has shown consistent efficacyin reversing behavioral and/or neurobiological alterations in well-established preclinical modelsof psychostimulant abuse and levodopa-induced dyskinesia. In addition, I will present selectedresults from our ongoing complementary studies, in which we have utilized recombinant virusvector and other latest “molecular” technique to elucidate the mechanisms underlying thetreatment efficacies of the combination treatments.