[초청강연] CLE peptide signaling in meristem maintenance

In multicellular organisms, intercellular communication is a fundamental mechanism for coordinating growth and differentiation. In the plant shoot apical meristem (SAM), CLAVATA (CLV) plays essential roles in regulating stem cell fate. CLV3 is a peptide ligand of Arabidopsis thaliana that interacts with the receptor complex of CLV1 and CLV2 to restrict the stem cell population in the SAM in a non-cell-autonomous manner. Synthetic CLV3 peptide treatment also function to reduce SAM and RAM size. Reporter gene activities of CLV3::GUS, CLV3::GFP, and WUS::GUS were decreased when these reporter lines were treated with CLV3 peptide. CLV3 did not function in the clv1 and clv2 mutants, indicating that the synthetic CLV3 function in the endogenous CLV signaling pathway. We isolated mutants, which are resistant against to the synthetic CLV3 peptides. These mutants can grow even on the agar medium including CLV3 peptides. Here we will discuss about these mutant and causal genes.