일시: 2022-12-09 11:00 ~ 13:00
발표자: Jeong-Mo Choi (PNU Dept. of Chemistry)
담당교수: 생명과학부
장소: 대면 | 목암홀(Mokam Hall) https://snu-ac-kr.zoom.us/j/95568098277
Molecular Grammar of Biomolecular Phase Separation
Jeong-Mo Choi1
1Department of Chemistry, Pusan National University, Busan 46241, Republic of Korea
*E-mail: jmchoi@pusan.ac.kr
In the last decade, there has been a growing interest on the phase behavior of biomolecules,
especially after demonstration of its biological implications such as reversible
formation/dissociation of membrane-less cellular organelles. Several model systems have been
discovered and studied, and one of crucial questions in the field is how the phase behavior is
encoded in a sequence. Inspired by observations on a subset of disordered proteins that
apparently exhibit a rather simple molecular grammar for phase behavior, we developed
stickers-and-spacers framework adapted from the field of associative polymers for
understanding how multivalent protein and RNA molecules drive phase transitions that give
rise to biomolecular condensates. In this talk, I will introduce the framework and discuss its
applications in explanation and prediction of biomolecular phase behaviors.