[초청강연] [2021학년도 1학기 금요세미나] Functional architecture of the high-level visual system in nonhuman primates: new insights from a naturalistic vision paradigm

Abstract

The primate visual system has been heavily studied and characterized using controlled experiments, with elemental visual stimuli presented during reduced behavioral paradigms. Measuring and interpreting brain activity during more natural conditions can offer complementary perspectives to traditional experiments and advance our understanding of how the brain approaches real-world vision problems. In this talk, I will present a series of work utilizing a more naturalistic paradigm in macaques and marmosets, where monkeys watch videos of their conspecifics interacting while moving their eyes freely. During this free-viewing of video, we measured neuronal responses at multiple spatiotemporal scales using electrophysiology, calcium imaging, and fMRI. We developed a novel single-unit fMRI mapping method that uses a set of videos as a common currency and offers a unique way of studying individual visual neurons during complex visual stimulation in the context of a whole-brain network, instead of namable visual features of the stimulus. Using this approach, we revealed that neighboring cells in macaque face-selective regions can participate in distinct visual operations, some of which are shared across spatially separated regions. In an on-going study in marmoset monkeys, we hope to find additional clues on how neurons in local circuitry interact differently depending on the viewing mode, by comparing responses of large populations of neurons during free viewing of videos with passive fixation on stationary images.



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