[초청강연] The molecular logic of intelligent circuits

Our brains use ion channel receptors and cell types to orchestrate neuronal information processing, the
basis for intelligent behavior. While the role of neuronal molecules like receptors and kinases have been
well-characterized in reduced systems, the impact of these molecules on the neuronal algorithm and in

vivo computation is largely unexplored. In this seminar, I will introduce my work developing in vivo two-
photon imaging techniques and novel kinase biosensors to advance the interrogation of cortical

information processing. Focusing on a mammalian-conserved molecular adaptation in GABAergic PV+
interneurons, my collaborators and I found that cell-type-specific transcriptional regulation of
neurotransmitter receptors suppresses the orientation selectivity of PV+ neurons in the visual cortex.
Remarkably, PV+ neurons in the hippocampus CA1 region which typically display broad spatial selectivity
in comparison to their neighboring excitatory ‘place’ cells are also governed by similar principles,
indicating that receptor regulation suppresses the selectivity of PV+ neurons in a modality-independent
fashion. Given the role of PV+ neurons in the canonical normalization computation, our findings
highlight a key molecular implementation of such cortical logic.