[초청강연] Rewiring organelle dynamics under nutrient stress - 유망과학자세미나

Abstract
Eukaryotic cells contain a variety of intracellular lipid membrane-bound compartments
called organelles that mediate the important biochemical functions necessary for life.
The field of studying organelle biology has recently grown fast owing to the advent of

new microcopy that allowed the high-resolution imaging of organelles and organelle-
specific probes. Consequently, unlike our classic textbook image of organelles usually

depicted as static and isolated, emerging pictures show organelles undergo dynamic
fusion, and fission, and actively communicate with each other by establishing close
apposition between the membranes of two organelles, the so-called membrane contact
sites. Rewiring such organelle dynamics is essential for cells to appropriately adapt to
altering environments such as nutrient deprivation. Unlike other organelles that have
multiple copies in cells, each cell contains only one ER. This ER extends throughout
the cell and occupies a large fraction of the cytoplasmic volume via its elaborate, giant
membrane architecture consisting of different morphological domains, namely tubule,
sheets, and nuclear envelope. However, the underlying mechanism of ER
morphological dynamics and the relationship between its form and function still remain
elusive. In this talk, I will present how cells reshape ER during nutrient starvation and
rewire their metabolic states by communicating with neighboring organelles.