[초청강연] Molecular recording using precision genome editing

1. 세미나 abstract:
Understanding how each cell type arises during cellular development is one of
the central questions in biology and medicine. While comprehensively
delineating cellular development requires tools to monitor both cell proliferation
and differentiation, the current technologies limit our observations to either
finely resolved cell states at a single time-point (e.g., single-cell profiling) or
poorly resolved cell states over time (e.g., time-resolved microscopy). Here, I
propose to develop molecular recording technology, a third paradigm to
observe cellular developments, using precision genome editing. Recording past
cellular events, both their lineage information and extracellular signaling, will
allow inference of which sequences of events program the cell-fate decision.