Professor
Shim, Jiwon
Research
Developmental Biology
Genetics
Immunology
Our research interests focus on exploring the long-range regulation of hematopoiesis via sensory perception and unexpected immune cell functions beyond their typical roles in innate immunity. Through our study, We aim to address the following fundamental questions in biology:
1) How do multiple organs interact together to maintain homeostatic balance in animals?
2) How do stem/progenitor cells coordinate their development in response to environmental changes?
3) Do immune cells function in the non-immunological context?
4) How can primitive immune cells of myeloid lineage evolve into colossally diverse vertebrate immune cells?
Education/Career
Education
- - 2008 Ph.D. : Seoul National University
- - 2004 M.S. : Yonsei University
- - 2002 B.S. : Yonsei University
Career
- - 2025-present Professor, School of Biological Sciences, Seoul National University
- - 2014-2025 Assistant, Associate Professor, and Professor, Department of Life Science, Hanyang University
- - 2009-2014 Postdoctoral Fellow, MCDB, UCLA
- - 2008 Postdoctoral Fellow, Institute of Molecular Biology and Genetics, Seoul National University
Publications
- M Shin*, E Chang*, D Lee*, N Kim, B Cho, N Cha, F Koranteng, JJ Song, and J Shim (2024) Drosophila immune cells transport oxygen through PPO2 protein phase transition, Nature, 631, 350-359
- B Cho, M Shin, E Chang, S Son, I Shin, and J Shim (2024) S-nitrosylation-triggered unfolded protein response maintains hematopoietic progenitors in Drosophila, Developmental Cell, 59(8), 1075-1090
- SH Yoon, B Cho, D Lee, H Kim, J Shim* and JW Nam* (2023) Molecular traces of Drosophila hemocytes reveal transcriptomic conservation with vertebrate myeloid cells, PLOS Genetics, 19(12), e1011077 (*Co-corresponding authors)
- H Li#, J Janssens#, M De Waegeneer, SS Kolluru, K Davie, V Gardeux, W Sealens, F David, M Brbic, J Leskovec, C McLaguphlin, Q Xie, R Jones, K Brueckner, J Shim, SG Tattikota, F Schnorrer, K Rust, T Nystul, Z Carvalho-Santos, C Ribeiro, S Pal, TM Przytycka, A Allen, S Goodwin, CW Berry, MT Fuller, H White-Cooper, E Matunis, S DiNardo, A Galenza, LE O’Brien, JAT Dow, H Jasper, B Oliver, N Perrimon*, B Deplancke*, S Quake*, L Luo*, and S Aerts*, FCA Consortium (2022) Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly, Science, 375 (6584): eabk2432
- S Madhwal, M Shin, M Joshi, A Kapoor, P MR R ehman, K Gor, J Shim* and T Mukherjee* (2020) Metabolic control of immune-competency by odors in Drosophila, eLife, 10, e60376 (*Co-corresponding authors)
- B Cho*, SH Yoon*, D Lee, F Koranteng, SG Tattikota, N Cha, M Shin, H Do, Y Hu, SY Oh, SJ Moon, N Perrimon, JW Nam*, and J Shim* (2020) Single-cell transcriptome maps of myeloid blood cell lineages in Drosophila, Nature Communications, 11(1), 4483 (*Co-corresponding authors)