Assistant Professor
Lee, Hong-Gyun
Research
Immunology
Neurobiology
Our research focuses on understanding how glial immunity controls health and disease in the central nervous system (CNS) and the enteric nervous system (ENS). Using advanced technologies, we investigate the dynamic interactions between glial cells and immune cells to understand inflammation and tissue homeostasis, aiming to develop novel therapeutic approaches for neurological and gastrointestinal disease.
Education/Career
Education
- - 2013.03 ~ 2020.02 Ph.D. in Life Science, Hanyang University
- - 2009.03 ~ 2013.02 B.S. in Life Science, Hanyang University
Career
- - 2025.03 ~ Present Assistant Professor, School of Biological Sciences, Seoul National University
- - 2021.03 ~ 2025. 01 Postdoctoral Research Fellow, Harvard Medical School | Brigham and Women’s Hospital
- - 2020.03 ~ 2021. 02 Postdoctoral Fellow, Hanyang University
Publications
- Lee HG, Rone JM, Li Z, Akl CF, Shin SW, Lee JH, Flausino LE, Pernin F, Chao CC, Kleemann KL, Srun L, Illouz T, Giovannoni F, Charabati M, Sanmarco LM, Kenison JE, Piester G, Zandee SEJ, Antel JP, Rothhammer V, Wheeler MA, Prat A, Clark IC, Quintana FJ. “Disease-Associated Astrocyte Epigenetic Memory Promotes CNS Pathology” Nature, 2024 Mar;627(8005):865-872.
- Lee HG*, Lee JH*, Flausino LE*, Quintana FJ. “Neuroinflammation: An Astrocyte Perspective” Sci Transl Med, 2023 Nov 8;15(721):eadi7828. (*denotes co-first author)
- Wheeler MA*, Clark IC*, Lee HG*, Li Z, Linnerbauer M, Rone JM, Blain M, Akl CF, Piester G, Giovannoni F, Charabati M, Lee JH, Kye YC, Choi J, Sanmarco LM, Srun L, Chung EN, Flausino LE, Andersen BM, Rothhammer V, Yano H, Illouz T, Zandee SEJ, Daniel C, Artis D, Prinz M, Abate AR, Kuchroo VK, Antel JP, Prat A, Quintana FJ. “Droplet-Based Forward Genetic Screening of Astrocyte-Microglia Cross-Talk” Science, 2023 Mar 10;379(6636):1023-1030. (*denotes co-first author)
- Lee HG*, Wheeler MA*, Quintana FJ. “Function and Therapeutic Value of Astrocytes in Neurologic Diseases” Nat Rev Drug Discov, 2022 May;21(5):339-358. (*denotes co-first author)
- Lee HG, Lee JU, Kim DH, Lim S, Kang IS, Choi JM. “Pathogenic Function of Bystander-activated Memory-like CD4+ T cells in Autoimmune Encephalomyelitis” Nat Commun, 2019 Feb 12;10(1):709.