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Center for Single Molecule Systems Biology

2019

Hyun-Kyu Choi, Duyoung Min, Hyunook Kang, Min Ju Shon, Sang-Hyun Rah, Hak Chan Kim, Hawoong Jeong, Hee-Jung Choi, James U. Bowie and Tae-Young Yoon (2019). Watching helical membrane proteins fold reveals a common N- to C-terminal folding pathway. Science, 366(6469), 1150-1156.

Nils Brose, Axel Brunger, David Cafiso, Edwin R. Chapman, Jiajie Diao, Frederick M. Hughson, Meyer B. Jackson, Reinhard Jahn, Manfred Lindau, Cong Ma, Josep Rizo, Yeon-Kyun Shin, Thomas H. Söllner, Lukas Tamm, Tae-Young Yoon & Yongli Zhang (2019). Synaptic vesicle fusion: today and beyond. Nature Structural & Molecular Biology, 26(), 663–668.

Tae-Young Yoon and Hong-Won Lee (2019). Shedding light on complexity of protein-protein interactions in cancer. Current Opinion in Chemical Biology, 53(), 75-81.

Min Ju Shon, Sang-Hyun Rah, Tae-Young Yoon (2019). Submicrometer elasticity of double-stranded DNA revealed by precision force-extension measurements with magnetic tweezers. Science Advances, 5(6), eaav1697.

Ji young Ryu, Jihye Kim, Min Ju Shon, Jiashu Sun, Xingyu Jiang, Wonhee Lee and Tae-Young Yoon (2019). Profiling protein-protein interactions for single cancer cells with in situ lysis and co-immunoprecipitation. Lab on a Chip, 19(), 1922-1928.

2018

Mi Sook Sung, Jik-Han Jung, Cherlhyun Jeong*, Tae-Young Toon*, and Ji-Ho Park* (2018). Single-Molecule Co-Immunoprecipitation Reveals Functional Inheritance of EGFRs in Extracellular Vesicles. Small, 14(42), 1802358.

[Video Abstract]

Min Ju Shon, Haesoo Kim, Tae-Young Yoon (2018). Focused clamping of a single neuronal SNARE complex by complexin under high mechanical tension. Nature Communications, 9(1), 3639.

Hong-Won Lee, Byoungsan Choi, Han Na Kang, Hyunwoo Kim, Ahrum Min, Minkwon Cha, Ji Young Ryu, Sangwoo Park, Jinyoung Sohn, Kihyuk Shin, Mi Ran Yun, Joo Yeun Han, Min Ju Shon, Cherlhyun Jeong, Junho Chung, Seung-Hyo Lee, Seock-Ah Im*, Byoung Chul Cho* and Tae-Young Yoon* (2018). Profiling of protein–protein interactions via single-molecule techniques predicts the dependence of cancers on growth-factor receptors. Nature Biomedical Engineering, 2(4), 239.

[Editorial] [News & Views]

Samantha I. Liang, Bettinavan Lengerich, Kelsie Eichel, Minkwon Cha, David M.Patterson, Tae-Young Yoon, Markvon Zastrow, Natalia Jura, and Zev J.Gartner (2018). Phosphorylated EGFR Dimers Are Not Sufficient to Activate Ras. Cell Reports, 22(10), 2593-2600.

Tae-Young Yoon and Mary Munson (2018). SNARE complex assembly and disassembly. Current Biology, 28(8), R397-R401.

2017

C. Kim, S.-H. Rah, T.-Y. Yoon (2017). Structural insights on ATP hydrolysis-driven mechanical work of AAA+ hexamers. Biodesign, 5(1), 1-11.

J.-K. Ryu, S. J. Kim, S.-H. Rah, J. I. Kang, H. E. Jung, D. Lee, H. K. Lee, J.-O. Lee, B. S. Park, T.-Y. Yoon, H. M. Kim (2017). Reconstruction of LPS Transfer Cascade Reveals Structural Determinants within LBP, CD14, and TLR4-MD2 for Efficient LPS Recognition and Transfer. Immunity, 46(1), 38-50.

[Faculty of 1000]

2016

J. Yoo, T.-S. Lee, B. Choi, M. J. Shon, T.-Y. Yoon (2016). Observing extremely weak protein-protein interactions with conventional single-molecule fluorescence microscopy. J. Am. Chem. Soc., 138(43), 14238-14241.

J.-K. Ryu, R. Jahn & T.-Y. Yoon (2016). Progresses in understanding NSF-mediated disassembly of SNARE complexes. Biopolymers, 105(8), 518-531.

Invited review; Special Issue for GTP and ATP Hydrolysis in Biology, edited by Alfred Wittinghofer

T.-S. Lee, J.-Y. Lee, J. W. Kyung, Y. Yang, S. J. Park, S. Lee, I. Pavlovic, B. Kong, Y.S. Jho, H.J. Jessen, D.H. Kweon, Y.-K. Shin, S.H. Kim, T.-Y. Yoon, S. Kim (2016). Inositol Pyrophosphates Inhibit Synaptotagmin-Dependent Exocytosis. PNAS, 113(29), 8314-8319.

J. Kim, H. Kang, J. Park, W. Kim, J. Yoo, N. Lee, J. Kim, T.-Y. Yoon & G. Choi (2016). PIF1-interacting transcription factors and their binding sequence elements determine the in vivo targeting sites of PIF1. Plant Cell, 28(), 1388-1405.

2015

D. Min, R. Jefferson, J. Bowie, & T.-Y. Yoon (2015). Mapping the energy landscape for second-stage folding of a single membrane protein. Nat. Chem. Biol., 11(), 981-987.

L. Zhang, Q. Feng, J. Wang, S. Zhang, B. Ding, Y. Wei, M. Dong, J.-Y. Ryu, T-.Y. Yoon, X. Shi, J. Sun, & X. Jiang (2015). Microfluidic Synthesis of Hybrid Nanoparticles with Controlled Lipid Layers: Understanding Flexibility-Regulated Cell-Nanoparticle Interaction. ACS Nano, 9(10), 9912-9921.

J.-K. Ryu, D. Min, S.-H. Rah, S. J. Kim, Y. Park, H. Kim, C. Hyeon, H. M. Kim, R. Jahn & T.-Y. Yoon (2015). Spring-loaded unraveling of a single SNARE complex by NSF in one round of ATP turnover. Science, 347(6229), 1485-1489.

[dongA.com] [EurekAlert!] [ScienceDaily] [PhysORG]

2014

W. Bae, K. Kim, D. Min, J.-K. Ryu, C. Hyeon & T.-Y. Yoon (2014). Programmed folding of DNA origami structures through single-molecule force control. Nat. Commun., 5(), 5654.

J. Y. Ryu, I. T. Song, K.H.A. Lau, P. B. Messersmith, T.-Y. Yoon & H. Lee (2014). New Anti-fouling Platform Characterized by Single-molecule Imaging. ACS Appl. Mater. Interfaces, 6(5), 3353-3358.

2013

Y. Lai, X. Lou, Y. Jho, T.-Y. Yoon & Y.-K. Shin (2013). The synaptotagmin 1 linker may function as an electrostatic zipper that opens for docking but closes for fusion pore opening. Biochem. J., 456(1), 25-33.

H.-W. Lee, J. Ryu, J. Yoo, B. Choi, K. Kim & T.-Y. Yoon (2013). Real-time single-molecule co-immunoprecipitation of weak protein-protein interactions (Invited contribution). Nat. Protoc., 8(10), 2045-2060.

W. Bae, M.-G. Choi, C. Hyeon, Y.-K. Shin & T.-Y. Yoon (2013). Real-Time Observation of Multiple-Protein Complex Formation with Single-Molecule FRET. J. Am. Chem. Soc., 135(28), 10254-10257.

D. Min, K. Kim, C. Hyeon, Y. H. Cho, Y.-K. Shin & T.-Y. Yoon (2013). Mechanical unzipping and rezipping of a single SNARE complex reveals hysteresis as a force-generating mechanism. Nat. Commun., 4(), 1705.

S. Heo, K. Kim, R. Christophe, T.-Y. Yoon, Y.-H. Cho (2013). Simultaneous detection of biomolecular interactions and surface topography using photonic forcemicroscopy. Biosensors and Bioelectronics, 42(), 106-111.

H.-W. Lee, T. Kyung, J. Yoo, T. Kim, C. Chung, J. Y. Ryu, H. Lee, K. Park, S. Lee, W. D. Jones, D.-S. Lim, C. Hyeon, W. D. Heo & T.-Y. Yoon (2013). Real-time single-molecule co-immunoprecipitation analyses reveal cancer-specific Ras signalling dynamics. Nat. Commun., 4(), 1515.

S. Cho, J. Jang, C. Song, H. Lee, P. Ganesan, T.-Y. Yoon, M. W. Kim, M. C. Choi, H. Ihee, W. D. Heo & Y. K. Park (2013). Simple super-resolution live-cell imaging based on diffusion-assisted Förster resonance energy transfer. Scientific Reports, 6(), 1208.

2012

J. Diao, Y. Ishitsuka, H. Lee, C. Joo, Z. Su, S. Syed, Y.-K. Shin, T.-Y. Yoon & T. Ha (2012). A single vesicle-vesicle fusion assay for in vitro studies of SNAREs and accessory proteins. Nat. Protoc., 7(5), 921-934.

2011

J.-H. Kang, K. Kim, H.-S. Ee, Y.-H. Lee, T.-Y. Yoon, M.-K. Seo & H.-G. Park (2011). Low-power nano-optical vortex trapping via plasmonic diabolo nanoantennas. Nat. Commun., 2(), 582.

M.-H. Seo, T.-S. Lee, E. Kim, Y. L. Cho, H.-S. Park, T.-Y. Yoon & H.-S. Kim (2011). Efficient Single-Molecule Fluorescence Resonance Energy Transfer Analysis by Site-Specific Dual-Labeling of Protein Using an Unnatural Amino Acid. Anal. Chem., 83(23), 8849-8854.

T.-Y. Yoon, D.-H. Kweon, Y.-K. Shin (2011). Chapter 7 - Chasing the Trails of SNAREs and Lipids Along the Membrane Fusion Pathway. Curr. Top. Membr., 68(), 161-184.

C. Jeong, W.-K. Cho, K.-M. Song, C. Cook, T.-Y. Yoon, C. Ban, R. Fishel & J.-B. Lee (2011). MutS Switches Between Two Fundamentally Distinct Clamps during Mismatch Repair. Nat. Struct. Mol. Biol., 18(3), 379-385.

2010

Y. Yang, J. Y. Shin, J.-J. Oh, C. H. Jung, Y. Hwang, S. Kim, J.-S. Kim, K.-J. Yoon, J.-Y. Ryu, J. Shin, J. S. Hwang, T.-Y. Yoon, Y.-K. Shin & D.-H. Kweon (2010). Dissection of SNARE-driven membrane fusion and neuroexocytosis by wedging small hydrophobic molecules into the SNARE zipper. PNAS, 107(51), 22145-22150.

H.-K. Lee, Y. Yang, Z. Su, C. Hyeon, T.-S. Lee, H.-W. Lee, D.-H. Kweon, Y.-K. Shin & T.-Y. Yoon (2010). Dynamic Ca2+-Dependent Stimulation of Vesicle Fusion by Membrane-Anchored Synaptotagmin 1. Science, 328(5979), 760-763.

[Editor's Choice] [ScienceDaily.com] [see also this PNAS commentary]

J. Diao, Z, Su, T.-Y. Yoon, Y.-K. Shin & T. Ha (2010). Single-Vesicle Fusion Assay Reveals Munc18-1 Binding to the SNARE Core is Sufficient for Stimulating Membrane Fusion. ACS Chem. Neurosci., 1(3), 168-174.

Y. Na, T.-Y. Yoon, S Park, B. Lee & S.-D. Lee (2010). Electrically Programmable Nematofluidics with a High Level of Selectivity in a Hierarchically Branched Architecture. Chem. Phys. Chem., 11(1), 101-104.

2009

J. Diao, T.-Y. Yoon, Z. Su, Y.-K. Shin & T. Ha (2009). C2AB: A Molecular Glue for Lipid Vesicles with a Negatively Charged Surface. Langmuir, 25(13), 7177-7180.

T.-Y. Yoon & Y.-K. Shin (2009). Progress in understanding the SNARE function and its regulation (Invited Review). Cell. Mol. Life Sci, 66(), 460-469.

2008

T.-Y. Yoon, X. Lu, J. Diao, T. Ha & Y.-K. Shin (2008). Complexin and Ca2+ stimulate SNARE-mediated membrane fusion. Nat. Struct. Mol. Biol., 15(7), 707-713.

2006

T.-Y. Yoon, B. Okumus, F. Zhang, Y.-K. Shin & T. Ha (2006). Multiple intermediates in SNARE-induced membrane fusion. PNAS, 103(52), 19731-19736.

[Faculty 1000] [PNAS commentary] [News and Views in NSMB]

Y.-T. Kim, J.-H. Hong, T.-Y. Yoon & S.-D. Lee (2006). Pixel-encapsulated flexible displays with a multifunctional elastomer substrate for self-aligning liquid crystals. Applied Physics Letters, 88(), 263581.

T.-Y. Yoon, C. Jeong, S.-W. Lee, J. H. Kim, M. C. Choi, S.-J. Kim, M. W. Kim & S.-D. Lee (2006). Topographic control of lipid-raft reconstitution in model membranes. Nature Materials, 5(), 281-285.

2005

C. Jeong, T.-Y. Yoon, S.-D. Lee, Y.-G. Park & H. Kwon (2005). Patterning Process of Membrane-associated Proteins on a Solid Support with Geometrical Grooves. Mol. Cryst. Liq. Cryst., 434(1), 297-303.

2004

T.-Y. Yoon, C. Jeong, J. H. Kim, M. C. Choi, M. W. Kim & S.-D. Lee (2004). Spontaneous aggregation of lipids in supported membranes with geometrical barriers. Applied Surface Science, 238(1-4), 299-303.

T.-Y. Yoon, C. Jeong, S.-J. Kim, C.-J. Yu & S.-D. Lee (2004). Undulation Patterns In Pattern Formation of Cholesteric Liquid Crystals as Wavelength-Changing Instabilities. Mol. Cryst. Liq. Cryst., 413(1), 489-497.

2003

J.-H. Park, Y. Choi, T.-Y. Yoon, C.-J. Yu & S.-D. Lee (2003). A self-aligned multi-domain liquid-crystal display on polymer gratings in a vertically aligned configuraion. J. Soc. Inf. Display, 11(2), 283-287.

T.-Y. Yoon, C.-J. Yu, W.-J. Lee, J.-S. Sim, J.-H. Park & S.-D. Lee (2003). Control of electric equi-potential in a liquid crystal film on a grating surface. Mol. Cryst. Liq. Cryst., 21(1-3), 647-650.

2002

T.-Y. Yoon, J.-H. Park, J. Sim & S.-D. Lee (2002). Self-formation of microdomains by the topographical and fringe field effects in a liquid crystal display with dielectric surface gratings. Applied Physics Letters, 81(13), 2361-2363.

Y.-J. Cho, T.-Y. Yoon, S.-D. Lee & H.-W. Rhee (2002). Laser Etchings on Polyimide Alignment Layers in Multi-Domain VA Mode. Mol. Cryst. Liq. Cryst., 377(1), 317-320.

T.-Y. Yoon, J.-H. Park, W.-J. Lee & S.-D. Lee (2002). Self-Induced Array of Micro-Domains in a Twisted Nematic Structure on a Surface Geometric Grating. Mol. Cryst. Liq. Cryst., 375(1), 215-223.

J.-H. Park, T.-Y. Yoon, W.-J. Lee & S.-D. Lee (2002). Multi-domain Liquid Crystal Display with Self-Aligned 4-domains on Surface Relief Gratings of Photopolymer. Mol. Cryst. Liq. Cryst., 375(1), 433-440.

T.-Y. Yoon, H. Baac & S.-D. Lee (2002). Optical Properties of a Chiral Liquid Crystal in a Generalized Coupled Mode Formalism. Mol. Cryst. Liq. Cryst., 371(), 203-206.

2001

T.-Y. Yoon & S.-D. Lee (2001). Analysis of the Optical Properties of a Helicoidal Liquid Crystal in a General Coupled Mode Formalism. Mol. Cryst. Liq. Cryst., 366(), 387-394.

1999

J.-H. Lee, H.-R. Kim, T.-Y. Yoon & S.-D. Lee (1999). Wavelength Selection in a Fabry-Perot Filter with an Axially Aligned Nematic Liquid Crystal. Mol. Cryst. Liq. Cryst, 337(), 19-24.